He is one of three potential changes for the side as Kalyn Ponga and Tim Glasby have both been named as part of the 18-man squad.
Anthony Milford has missed selection after being a late inclusion to replace the injured Slater for Game 1, while Michael Morgan will be forced to miss the rest of the series due to a bicep injury.
What seems most likely is that Slater will come in for Morgan at fullback, with Ponga tipped to make a debut for the Maroons on the bench.
Glasby’s inclusion might depend on whether or not Dylan Napa is fully recovered from an ankle injury in time to play.
The current expectation is that he will be fit for Origin 2, but an 18-man squad suggests the Maroons are keen to have some insurance.
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Queensland Maroons squad for Origin 2
Jai Arrow (Gold Coast Titans)
Will Chambers (Melbourne Storm)
Gavin Cooper (North Queensland Cowboys)
Dane Gagai (South Sydney Rabbitohs)
Tim Glasby (Melbourne Storm)
Coen Hess (North Queensland Cowboys)
Valentine Holmes (Cronulla Sharks)
Ben Hunt (St George Illawarra Dragons)
Greg Inglis – captain (South Sydney Rabbitohs)
Felise Kaufusi (Melbourne Storm)
Andrew McCullough (Brisbane Broncos)
Josh McGuire (Brisbane Broncos)
Cameron Munster (Melbourne Storm)
Dylan Napa (Sydney Roosters)
Josh Papalii (Canberra Raiders)
Kalyn Ponga (Newcastle Knights)
Billy Slater (Melbourne Storm)
Jarrod Wallace (Gold Coast Titans)